Autism and the Microbiome [WEBINAR]

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Recent research indicates that autism spectrum disorder (ASD) and conditions of similar pathology, like celiac disease and IBD, can be triggered by both intrinsic and extrinsic factors, including environmental toxins like glyphosate, dietary alterations, metabolic status, and intestinal permeability. An overgrowth of Clostridia and deficiency of Bifidobacteria appear to be common in patients with ASD. In this webinar, we will explore the similarities between celiac disease and ASD and discuss the best dietary and lifestyle interventions for these patients.

A 2015 review paper published in the Drug Metabolism and Disposition journal determined that probiotics could be useful for ASD therapy if they meet the following criteria:
1. Ability to alter host immunity by increasing secretory IgA, lower inflammatory markers, etc
2. Restoration of normal commensal gut flora
3. Suppression of microbial pathogens
4. Ability to improve intestinal barrier
5. Promote the synthesis of antioxidants

Interestingly, MegaSporeBiotic meets all five of these criteria. Bacterial spores, like those found in MegaSporeBiotic, can improve mucosal immunity and reduce inflammatory markers. They can shift the microbiome to restore normal commensal gut flora, suppress pathogenic overgrowths like Clostridia, and squelch opportunistic pathogens through the use of quorum sensing. MegaSporeBiotic has also been shown to help heal the intestinal barrier by up-regulating mucin 2 production. Furthermore, MegaSporeBiotic contains the only probiotic strain to date with antioxidant properties, Bacillus indicus HU36, that produces RDA levels of antioxidants at the site of absorption.

For these reasons, MegaSporeBiotic should be an integral component of any ASD treatment plan.

References

Claus SP, Guillou H, Ellero-Simatos S. The gut microbiota: a major player in the toxicity of environmental pollutants? NPJ Biofilms Microbiomes. 2016;2:16003.

Parracho HM, Bingham MO, Gibson GR, McCartney AL. Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children. J Med Microbiol. 2005;54(10):987-91.

Rosenfeld CS. Microbiome Disturbances and Autism Spectrum Disorders. Drug Metab Dis. 2015;43(10):1557-1571.

Samsel A, Seneff S. Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases. Entropy. 2013;15(4):1416-1463.

Song Y, Liu C, Finegold SM. Real-time PCR quantitation of clostridia in feces of autistic children. Appl Environ Microbiol. 2004;70(11):6459-65.

Wang LV, Christophersen CT, Sorich MJ, et al. Elevated Fecal Short Chain Fatty Acid and Ammonia Concentrations in Children with Autism Spectrum Disorder. Digestive Diseases and Sciences. 2012;57(8):2096-2102.

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