{"id":1750,"date":"2023-10-16T13:56:13","date_gmt":"2023-10-16T13:56:13","guid":{"rendered":"http:\/\/localhost:10018\/home\/?p=1750"},"modified":"2025-09-25T14:58:49","modified_gmt":"2025-09-25T14:58:49","slug":"published-studies","status":"publish","type":"post","link":"https:\/\/microbiomelabs.com\/home\/published-studies\/","title":{"rendered":"Published Studies"},"content":{"rendered":"
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Spore Studies<\/h2>\n<\/div>\n<\/div>\n
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Form\/Duration<\/p>\n<\/div>\n<\/th>\n

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Study Details and Results<\/p>\n<\/div>\n<\/div>\n<\/th>\n

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Reference<\/p>\n<\/div>\n<\/th>\n<\/tr>\n<\/thead>\n

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Bacillus subtilis<\/em> (HU58\u2122)<\/strong><\/p>\n

4 weeks<\/p>\n<\/div>\n<\/td>\n

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Daily treatment with oral Bacillus subtilis<\/em> HU58\u2122 for 4 weeks was safe and well-tolerated in study subjects. HU58\u2122 supported healthy blood ammonia levels.<\/p>\n<\/div>\n<\/td>\n

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DOI: 10.1155\/2020\/1463108<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

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Bacillus subtilis<\/em> (HU58\u2122)<\/strong><\/p>\n

15 days<\/p>\n<\/div>\n<\/td>\n

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HU58\u2122 reduced stool from 7-8 stools per day to 1-2 stools per day. Significant improvement\u202fwas observed in 16 study subjects (scale 4), mild improvement observed in 6 study subjects (scale 5) and no improvement\u202fwas observed in 8 study subjects (scale 6). HU58\u2122 was safe, well-tolerated and effective in study subjects.<\/p>\n<\/div>\n<\/td>\n

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The Indian Practitioner<\/i>,\u00a073<\/i>(4), 22-28.<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

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Bacillus subtilis<\/em> (HU58\u2122)<\/strong><\/p>\n

8 weeks<\/p>\n<\/div>\n<\/td>\n

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Supplementation with 2 billion CFUs of Bacillus subtilis<\/em> HU58\u2122 was shown to support immune function and is well tolerated and safe for consumption in humans.<\/p>\n<\/div>\n<\/td>\n

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The Indian Practitioner<\/i>,\u00a070<\/i>(9), 15-20.<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

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MegaDuo\u2122 (RestorFlora\u2122)<\/strong><\/p>\n

2 weeks<\/p>\n<\/div>\n<\/td>\n

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MegaDuo\u2122 was shown to support intestinal epithelial barrier function and immune function.DOI:<\/p>\n<\/div>\n<\/td>\n

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DOI:10.3390\/microorganisms8071028<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

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MegaDuo\u2122 (RestorFlora\u2122)<\/strong> and PreticX\u00ae Xylooligosaccharide (MegaPre\u2122)
<\/strong>90 days<\/p>\n<\/div>\n<\/td>\n

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MegaDuo\u2122 (RestorFlora\u2122) and PreticX\u00ae Xylooligosaccharide (MegaPre\u2122) were shown to support the body\u2019s metabolic processes thereby promoting general health and wellbeing.<\/p>\n<\/div>\n<\/td>\n

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DOI: 10.1186\/s12263-022-00718-7<\/p>\n<\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n<\/section>\n

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Total Gut Restoration Studies<\/h2>\n<\/div>\n
<\/div>\n<\/div>\n
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Form\/Duration<\/p>\n<\/div>\n<\/th>\n

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Study Details and Results<\/p>\n<\/div>\n<\/th>\n

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Reference<\/p>\n<\/div>\n<\/th>\n<\/tr>\n<\/thead>\n

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Total Gut Restoration<\/strong><\/p>\n

in vitro<\/em> (M-SHIME\u00ae)<\/p>\n<\/div>\n

<\/div>\n<\/td>\n
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Fecal samples were used in vitro to evaluate the effects on the gut microbiome using the Total Gut Restoration supplementation system. TGR supplementation resulted in short-chain fatty acids (SCFAs) production and supported intestinal barrier function and immune function.<\/p>\n<\/div>\n<\/td>\n

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DOI: suppl\/10.2217\/fmb-2022-0066<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

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MegaSporeBiotic\u2122 and MegaMucosa\u2122<\/strong><\/p>\n<\/div>\n

<\/div>\n<\/td>\n
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The combination of MegaSpore\u2122 and MegaMucosa\u2122 promoted immune function and provided support to colonic mucosa.<\/p>\n<\/div>\n<\/td>\n

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DOI: 10.3390\/nu12123607<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

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MegaSporeBiotic\u2122<\/strong><\/p>\n

10 days<\/p>\n<\/div>\n

<\/div>\n<\/td>\n
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300 million CFU of MegaSporeBiotic\u2122 supplementation supported immune function and iron levels in mice.<\/p>\n<\/div>\n<\/td>\n

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DOI:10.1002\/jpen.1851<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

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MegaSporeBiotic\u2122<\/strong><\/p>\n

12 weeks<\/p>\n<\/div>\n<\/td>\n

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12 weeks of supplementation with MegaSporeBiotic\u2122 supported triglyceride levels in study subjects.<\/p>\n<\/div>\n<\/td>\n

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PMID: <\/span>33041703<\/span><\/p>\n<\/div>\n<\/td>\n<\/tr>\n

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MegaSporeBiotic\u2122<\/strong><\/p>\n<\/div>\n<\/td>\n

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Administration of MegaSporeBiotic\u2122 was shown to support liver function.<\/p>\n<\/div>\n<\/td>\n

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DOI: 10.3390\/nu12030632<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

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MegaSporeBiotic\u2122<\/strong><\/p>\n

60 days<\/p>\n<\/div>\n<\/td>\n

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MegaSporeBiotic\u2122 provided relief for occasional abdominal discomfort and supported elimination and digestive health in study subjects.<\/p>\n<\/div>\n<\/td>\n

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DOI: 10.3390\/nu11091968<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

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MegaSporeBiotic\u2122<\/strong><\/p>\n

30 days<\/p>\n<\/div>\n<\/td>\n

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MegaSporeBiotic\u2122 demonstrated cardiac-supportive and immune-supportive properties.<\/p>\n<\/div>\n<\/td>\n

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DOI:10.4291\/wjgp.v8.i3.117<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

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MegaSporeBiotic\u2122 and MegaPre\u2122<\/strong><\/p>\n<\/div>\n<\/td>\n

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MegaSporeBiotic\u2122 and MegaPre\u2122 promoted microbial diversity in the transverse and descending colon. Additionally, this synbiotic combination promoted the production of all SCFAs in the gut, including acetate, propionate, and butyrate.<\/p>\n<\/div>\n<\/td>\n

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DOI:10.1016\/j.ijpx.2019.100021<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

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MegaSporeBiotic\u2122 <\/strong><\/p>\n

3 weeks<\/p>\n<\/div>\n<\/td>\n

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MegaSporeBiotic\u2122 promoted bacterial diversity and supported ammonia, propionate, and lactate levels.<\/p>\n<\/div>\n<\/td>\n

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DOI:10.1016\/j.foodres.2021.110676<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

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MegaSporeBiotic\u2122 and antibiotics<\/strong><\/p>\n<\/div>\n

<\/div>\n<\/td>\n
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MegaSporeBiotic\u2122 was shown to support immune system health and help maintain normal intestinal flora.<\/p>\n<\/div>\n<\/td>\n

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DOI:10.3390\/microorganisms10061178<\/p>\n<\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n<\/section>\n

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Metabolic Support Studies<\/h2>\n
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Form\/Duration<\/p>\n<\/div>\n<\/th>\n

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Study Details & Results<\/p>\n<\/div>\n<\/th>\n

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Reference<\/p>\n<\/div>\n<\/div>\n<\/th>\n<\/tr>\n<\/thead>\n

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MyoMax\u2122<\/strong><\/p>\n

8 Weeks<\/p>\n<\/div>\n<\/td>\n

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Randomized, double-blind, placebo-controlled trial. 26 participants. Supplementation with MyoMax\u2122 was associated with a 12% increase in maximal cardiac output in aerobically trained athletes.<\/p>\n<\/div>\n<\/td>\n

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PMID:\u00a0<\/span>28646812<\/span><\/p>\n<\/div>\n<\/td>\n<\/tr>\n

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MenaquinGold\u00ae Natural MK (MyoMax\u2122, MegaQuinD3\u2122, MegaQuinone\u2122)<\/strong><\/p>\n

7\/ 12 Weeks<\/p>\n<\/div>\n<\/td>\n

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Randomized, double-blind, placebo-controlled trial. 42 participants. 180 -360 mcg of vitamin K2 (MK-7) was shown to support bone health.<\/p>\n<\/div>\n<\/td>\n

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DOI:10.1017\/S0007114511007185<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

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MenaquinGold\u00ae Natural MK (MyoMax\u2122, MegaQuinD3\u2122, MegaQuinone\u2122)<\/strong><\/p>\n

7\/ 8 Weeks<\/p>\n<\/div>\n<\/td>\n

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Randomized, double-blind, placebo-controlled study. 60 participants. Vitamin K2 (MK-7) was well tolerated and displayed to support nerve function health.<\/p>\n<\/div>\n<\/td>\n

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The Ind. Pract. 2010; 63(5):287-291<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

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MenaquinGold\u00ae Natural MK (MyoMax\u2122, MegaQuinD3\u2122, MegaQuinone\u2122)<\/strong><\/p>\n

3 months<\/strong><\/p>\n<\/div>\n<\/td>\n

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Open-labelled ambulant trial. 19 participants. MenaquinGold\u00ae Natural MK (MyoMax\u2122, MegaQuinD3\u2122, MegaQuinone\u2122) was well tolerated and safe with a relief of occasional muscle cramps.<\/p>\n<\/div>\n<\/td>\n

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The Ind. Pract. 2010; 63(5):287-291<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

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MenaquinGold\u00ae Natural MK (MyoMax\u2122, MegaQuinD3\u2122, MegaQuinone\u2122)<\/strong><\/p>\n<\/div>\n<\/td>\n

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In vitro. <\/em>MK-7 is able to support immune function<\/p>\n<\/div>\n<\/td>\n

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DOI: 10.1089\/jmf.2016.0030<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

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MenaquinGold\u00ae Natural MK (MyoMax\u2122, MegaQuinD3\u2122, MegaQuinone\u2122)<\/strong><\/p>\n

7\/ 8 weeks<\/p>\n<\/div>\n<\/td>\n

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Open-labeled observational study. 100 participants. Vitamin MK-7 was well tolerated and displayed to support nerve function health.<\/p>\n<\/div>\n<\/td>\n

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DOI: 10.4103\/jpp.JPP_72_18<\/p>\n<\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n<\/section>\n

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Pet Health Studies<\/h2>\n
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Form\/Duration<\/p>\n<\/div>\n<\/th>\n

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Study Details and Results<\/p>\n<\/div>\n<\/th>\n

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Reference<\/p>\n<\/div>\n<\/th>\n<\/tr>\n<\/thead>\n

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FidoSpore\u2122<\/strong><\/p>\n

30 days<\/p>\n<\/div>\n<\/td>\n

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Spore-based probiotics support digestive health in dogs.<\/p>\n<\/div>\n<\/td>\n

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DOI: 10.3390\/ani11051367<\/p>\n<\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

<\/div>\n<\/div>\n<\/section>\n
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<\/h2>\n

Skin Support Studies<\/h2>\n
<\/div>\n<\/div>\n
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Form\/Duration<\/p>\n<\/div>\n

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Study Details and Results<\/p>\n<\/div>\n

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Reference<\/p>\n<\/div>\n

<\/div>\n<\/th>\n<\/tr>\n<\/thead>\n
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MegaSporeBiotic\u2122<\/p>\n

8 weeks<\/p>\n<\/div>\n<\/td>\n

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Single-blinded, 25 participants. Probiotic supplementation helped retain moisture in skin. Probiotic supplementation supports skin health in those with skin issues & improved complexion for those with skin issues. Placebo for the first 4 weeks, followed by 4 weeks of probiotic supplementation.<\/p>\n<\/div>\n<\/td>\n

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DOI:10.3390\/jcm12030895<\/p>\n<\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

<\/div>\n<\/div>\n<\/section>\n
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<\/h2>\n

Immune Support Studies<\/h2>\n

 <\/p>\n

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Form\/Duration<\/p>\n<\/div>\n<\/th>\n

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Study Details and Results<\/p>\n<\/div>\n<\/th>\n

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Reference<\/p>\n<\/div>\n<\/th>\n<\/tr>\n<\/thead>\n

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Pylopass\u00ae (PyloGuard\u2122)<\/strong><\/p>\n

28 days and
\n56 days<\/p>\n<\/div>\n

<\/div>\n<\/td>\n
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Placebo-controlled trial 103 participants, children 9-17 years
\nSupported ammonia levels in Pylopass\u00ae (PyloGuard\u2122) group
\nPylopass\u00ae (PyloGuard\u2122) group reported higher rate of abdominal relief and reduced incidence of diarrhea<\/p>\n<\/div>\n<\/td>\n

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DOI: 10.15406\/ghoa.2020.11.00407<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

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Pylopass\u00ae (PyloGuard\u2122)<\/strong><\/p>\n

2 weeks<\/p>\n<\/div>\n

<\/div>\n<\/td>\n
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Pilot study 27 participants
\nDSM17648 co-aggregates with human strain of H. pylori<\/em> without aggregating with any other commensal bacteria.Supplementation supported levels of H. pylori.<\/em><\/p>\n<\/div>\n<\/td>\n

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DOI: 10.1007\/s12602-014-9181-3<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

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Pylopass\u00ae (PyloGuard\u2122)<\/strong><\/p>\n

4 weeks<\/p>\n<\/div>\n

<\/div>\n<\/td>\n
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Placebo-controlled, single-blind study 24 participants
\nSupported H.pylori<\/em> levels and improvement of abdominal discomfort<\/p>\n<\/div>\n<\/td>\n

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DOI: 10.1186\/s40795-018-0257-4<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

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Pylopass\u00ae (PyloGuard\u2122)<\/strong><\/p>\n

4 weeks<\/p>\n<\/div>\n

<\/div>\n<\/td>\n
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Clinical study 30 participants
\nSupported H. pylori<\/em> levels
\nPositive dynamics of occasional GI issues<\/p>\n<\/div>\n<\/td>\n

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DOI:\u00a010.1016\/j.imr.2014.04.001<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

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Pylopass\u00ae (PyloGuard\u2122)<\/strong><\/p>\n

2 weeks<\/p>\n<\/div>\n

<\/div>\n<\/td>\n
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Placebo controlled study 22 participants
\nSupported H. pylori<\/em> levels
\nEffect still observed 6 months after end of supplementation<\/p>\n<\/div>\n<\/td>\n

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DOI: 10.3390\/nu5083062<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

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Pylopass\u00ae (PyloGuard\u2122)<\/strong><\/p>\n

4 weeks<\/p>\n<\/div>\n

<\/div>\n<\/td>\n
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Randomized, double blind, placebo-controlled clinical study 200 participants
\nSignificant improvement of side effects compared to placebo group
\nPromoted abundance of Fusicatenibacter, Subdoligranulum, and Faecalibacterium
\n<\/em>Mean GSRS score decreased significantly in the LR group as compared with the placebo group<\/p>\n<\/div>\n<\/td>\n

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DOI: 10.1111\/hel.12856<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

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Pylopass\u00ae (PyloGuard\u2122)<\/strong><\/p>\n

2 weeks<\/p>\n<\/div>\n

<\/div>\n<\/td>\n
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90 participants Prospective and interventional randomized, double-center study. 86% eradication rate in Pylopass\u00ae (PyloGuard\u2122) group. 20% higher eradication rate compared to standard therapy group. Significant reduction in symptoms compared to standard therapy group.<\/p>\n<\/div>\n<\/td>\n

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DOI: 10.9734\/jpri\/2021\/v33i52B33611<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

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Mega IgG2000<\/strong><\/p>\n

2 weeks<\/p>\n<\/div>\n

<\/div>\n<\/td>\n
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In a randomized, double-blind, placebo-controlled, pilot study evaluating SBI in children
\n8-18 y with d-IBS, we collected stool number, abdominal pain, and stool type for 1 wk. We assigned patients at a ratio of 2:1 to SBI 5 gm BID or placebo for 3 wk. Patients and parents completed Pediatric Quality of Life Inventory for Gastrointestinal Symptoms (PedsQOL), the Pediatric Functional Disability Index (FDI), complete blood counts and serum chemistries at the start and end of treatment. Fifteen patients (9 SBI, 6 placebo) completed the study. Both groups reported reductions in stools\/wk and abdominal pain, and improved stool form. There was a trend for fewer stools in the SBI group compared to placebo. FDI and PedsQOL scores improved. in the SBI group, but not placebo. No serious adverse events occurred. SBI was safe in children with d-IBS, with improvement in symptoms.<\/p>\n<\/div>\n<\/td>\n

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DOI: 10.2147\/PHMT.S159925<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

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Mega IgG2000\u00a0 <\/strong><\/p>\n

duration and dose unspecified<\/p>\n<\/div>\n

<\/div>\n<\/td>\n
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White Paper- Summary<\/em><\/strong> Immunoglobulins in SBI have been shown to bind to a variety of conserved microbial antigens that are associated with immune activation (e.g. LPS, flagellin). Commensal-specific immunoglobulins (e.g. IgG, IgM, IgA) occur naturally in both plasma and the gastrointestinal tract. Preclinical studies demonstrate that SBI does not adversely affect the growth of commensal & probiotic bacteria in vitro or cause changes in the intestinal microbiota in an animal model used to evaluate host-microbiota relationships. Data from human studies indicate no significant changes in commensal microflora following oral administration of EnteraGam. Commensal-specific immunoglobulins likely provide a health benefit by supporting gut homeostasis and immune regulation activation.<\/p>\n<\/div>\n<\/td>\n

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Proliant Health (2016). EnteraGam: Managing Gastrointestinal Conditions While Not Harming Beneficial Bacteria<\/em> [White Paper]<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

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Mega IgG2000<\/strong><\/p>\n<\/div>\n

<\/div>\n<\/td>\n
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Serum\u2010derived bovine immunoglobulin (SBI) is a protein isolate rich in immunoglobulins for oral administration to improve immune health. SBI reduces inflammation by binding and neutralizing a variety of inflammatory antigens, improving gut epithelial barrier integrity, and maintaining gut homeostasis. In this study, fluorescence spectroscopy was used to demonstrate and quantify the binding of SBI to the fungal mycotoxins, aflatoxin G1 (AFG1) and aflatoxin B2 (AFB2). Calculated binding constants reveal SBI binds with both AFG1 and AFB2 in a dose dependent manner, likely through immunoglobulin\u2010aflatoxin interactions.<\/p>\n<\/div>\n<\/td>\n

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Proliant Health (2023). Mycotoxin Binding to SBI and Bovine Immunoglobulins<\/em> [White Paper]<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

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Mega IgG2000<\/strong><\/p>\n

5g, ex-vivo study<\/p>\n<\/div>\n

<\/div>\n<\/td>\n
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When dosed at an equivalent of 5 g\/day, all protein fractions significantly increased health-related metabolites\u2014acetate, propionate, and butyrate. Upon simulating small intestinal absorption, SBI still markedly increased acetate and propionate, demonstrating that SBI is more resistant to small intestinal digestion and absorption compared to the other protein sources.<\/p>\n<\/div>\n<\/td>\n

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DOI: 10.3390\/microorganisms11030659<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

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Lactobacillus <\/strong><\/em>LGG\u00ae<\/strong> + Bifidobacterium <\/strong><\/em>BB-12\u00ae <\/strong>(EpicDefense)<\/strong><\/p>\n<\/div>\n

<\/div>\n<\/td>\n
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Randomized, double-blind, placebo-controlled trial 12 weeks | 198 human subjects
\n\u2193 Respiratory discomfort duration & severity
\n\u2191 Health-related quality of life (HRQL)<\/p>\n<\/div>\n<\/td>\n

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DOI: 10.1017\/S0007114512004138<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

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Lactobacillus <\/strong><\/em>LGG\u00ae<\/strong> + Bifidobacterium <\/strong><\/em>BB-12\u00ae <\/strong>(EpicDefense)<\/strong><\/p>\n<\/div>\n<\/td>\n

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In vivo<\/em> studies
\n\u2191 Gut microflora balance
\n\u2191 Beneficial bacteria growth
\n\u2191 Microbiome health<\/p>\n<\/div>\n<\/td>\n

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DOI: 10.1080\/23311932.2018.1452839<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

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Lactobacillus <\/strong><\/em>LGG\u00ae<\/strong> \u00a0<\/strong>(EpicDefense)<\/strong><\/p>\n<\/div>\n<\/td>\n

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Randomized, double-blind, placebo-controlled trial 3 months | 281 children
\n\u2191 Respiratory health
\n\u2193 Respiratory instances lasting more than three days
\n\u2193 Days with respiratory discomfort<\/p>\n<\/div>\n<\/td>\n

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DOI: 10.1016\/j.clnu.2009.09.008<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

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Bifidobacterium <\/strong><\/em>BB-12\u00ae<\/strong> (EpicDefense)<\/strong><\/p>\n<\/div>\n<\/td>\n

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Randomized, double-blind, placebo-controlled trial 6 weeks | 211 human subjects
\n\u2191 IgG
\n\u2191IgA levels
\n\u2191 Total antibody concentrations<\/p>\n<\/div>\n<\/td>\n

\n
\n

DOI: 10.1016\/j.clnu.2009.09.008<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

\n
\n

EpiCor\u00ae<\/strong> (EpicDefense)<\/strong><\/p>\n<\/div>\n<\/td>\n

\n
\n

Randomized, double-blind, placebo-controlled trial 12 weeks | 96 human subjects
\n\u2191 Nasal & airflow comfort
\n\u2193 Nasal discharge
\n\u2193 Nasal concerns severity & duration<\/p>\n<\/div>\n<\/td>\n

\n
\n

DOI: 10.1007\/s12325-009-0057-y<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

\n
\n

Zinc<\/strong>\u00a0(EpicDefense)<\/strong><\/p>\n<\/div>\n<\/td>\n

\n
\n

Investigative study 14 days 54 human subjects
\n\u2191 Natural Killer cell functionality
\n\u2193 Circulating innate lymphoid cell counts & frequencies<\/p>\n<\/div>\n<\/td>\n

\n
\n

DOI: 10.1186\/s12967-025-06259-y<\/p>\n<\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n

<\/div>\n<\/section>\n
\n
\n

<\/h2>\n

Cognitive Support Studies<\/h2>\n
<\/div>\n<\/div>\n
\n
\n\n\n\n\n\n\n\n\n
\n
\n

Form\/Duration<\/p>\n<\/div>\n<\/th>\n

\n
\n

Study Details and Results<\/p>\n<\/div>\n<\/th>\n

\n
\n

Reference<\/p>\n<\/div>\n<\/th>\n<\/tr>\n<\/thead>\n

\n
\n

Bifidobacterium longum<\/em><\/strong><\/p>\n

1714\u00ae (Zenbiome Cope\u2122 & Sleep\u2122)<\/strong><\/p>\n

4 weeks<\/p>\n<\/div>\n<\/td>\n

\n
\n

Placebo-controlled study. 22 participants. 1714\u00ae strain supported cortisol levels and reduced perceived stress levels throughout the study compared to the placebo group. Significantly lower perceived stress levels in those participants taking B. longum 1714\u00ae compared to the placebo group. Bifidobacterium longum<\/em> 1714\u00ae (Zenbiome Cope\u2122 & Sleep\u2122)<\/p>\n<\/div>\n<\/td>\n

\n
\n

DOI: 10.1038\/tp.2016.191<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

\n
\n

Bifidobacterium longum<\/em><\/strong><\/p>\n

1714\u00ae (Zenbiome Cope\u2122 & Sleep\u2122)<\/strong><\/p>\n

4 weeks<\/p>\n<\/div>\n<\/td>\n

\n
\n

Randomized, double-blinded, placebo-controlled trial. 40 participants. 1714\u00ae strain supported relaxation reduced stress, and enhanced mood Difference of neural activity change during resting state in theta band after 1714\u00ae- promoted theta brainwave activity at rest, compared to the placebo group. Difference of neural activity change during resting state in beta 2 band after 1714\u00ae supported body\u2019s adaptation to beta 2 brain wave activity at rest, compared to the placebo group.<\/p>\n<\/div>\n<\/td>\n

\n
\n

DOI: 10.14309\/ajg.0000000000000203<\/a><\/p>\n<\/div>\n<\/td>\n<\/tr>\n

\n
\n

Bifidobacterium longum<\/em><\/strong><\/p>\n

1714\u00ae (Zenbiome Cope\u2122 & Sleep\u2122)<\/strong> 4 weeks<\/p>\n<\/div>\n<\/td>\n

\n
\n

Double-blind, randomized, placebo-controlled, repeated measures, cross-over design. 20 participants. Overall sleep quality and duration of sleep improved significantly in the probiotic treated group during exam stress compared with the placebo treated group.<\/p>\n<\/div>\n<\/td>\n

\n
\n

DOI: 10.1016\/j.bbih.2020.100174<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

\n
\n

Bifidobacterium longum<\/em> 1714\u00ae and Bifidobacterium longum<\/em> 35624\u00ae (Zenbiome Cope\u2122 & Sleep\u2122)<\/strong><\/p>\n

8 weeks<\/p>\n<\/div>\n<\/td>\n

\n
\n

Open label exploratory study. 40 participants. This exploratory open-label study found that 82% of subjects had significantly improved issues after 8 weeks, with 66% of subjects significantly improving after 4-weeks (issue severity score change of \u2265 50) in the moderate to severe group. The combination solution improved each of the individual issues (occasional abdominal discomfort, distension, bowel satisfaction), as well as an improvement in their quality of life. Participants in this group also had a significant improvement in their morning cortisol awakening response, a physiological biomarker of stress, after 4-weeks.<\/p>\n<\/div>\n<\/td>\n

\n
\n

DOI: 10.1111\/nmo.14477<\/p>\n<\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"

Spore Studies Form\/Duration Study Details and Results Reference Bacillus subtilis (HU58\u2122) 4 weeks Daily treatment with oral Bacillus subtilis HU58\u2122 for 4 weeks was safe and well-tolerated in study subjects. HU58\u2122 supported healthy blood ammonia levels. DOI: 10.1155\/2020\/1463108 Bacillus subtilis (HU58\u2122) 15 days HU58\u2122 reduced stool from 7-8 stools per day to 1-2 stools per […]<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1750","post","type-post","status-publish","format-standard","hentry","category-blog"],"acf":[],"yoast_head":"\nPublished Studies | Microbiome Labs<\/title>\n<meta name=\"description\" content=\"Spore Studies Form\/Duration Study Details and Results Reference Bacillus subtilis (HU58\u2122) 4 weeks Daily treatment with oral Bacillus subtilis HU58\u2122 for 4\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/microbiomelabs.com\/home\/published-studies\/\" \/>\n<meta property=\"og:locale\" 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