MegaQuinone K2-7

COMPLETE K2 FORMULA

MegaQuinone K2-7 is a high-dose, 100% soy-free formulation of natural vitamin K2 (MK-7) formulated for optimal bone, nerve, and heart health. This formula includes 320 mcg of vitamin K2 with vitamin K1 and chelated minerals for absorption. Given the major health benefits, vitamin K2 is arguably the most important dietary supplement out there, primarily because it can’t be found in sufficient quantities in the average Western diet.

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At a Glance

What is MegaQuinone?

MegaQuinone is a high-dose, 100% soy-free formulation of natural vitamin K2 (MK-7) formulated for optimal bone, nerve, and heart health. This formula includes 320 mcg of vitamin K2 with vitamin K1 and chelated minerals for absorption.

Given the major health benefits, vitamin K2 is arguably the most important dietary supplement out there, primarily because it can’t be found in sufficient quantities in the average Western diet.

Some of the early evidence of vitamin K2 came from Eastern Japan, where it is very common to consume natto, a naturally fermented soy product rich in vitamin K2. Researchers noticed that the rates of osteoporosis, diabetes, senile dementia, and heart disease were much lower in Eastern Japan compared to Western Japan- and certainly far lower than the rates in the US. With over 2000 published studies in the last 10 years, scientists have confirmed that the health benefits experienced by the Eastern Japanese, comes from this crucial nutrient – vitamin K2.

In the last 40 years, researchers have realized that vitamin K2 is responsible for activating, or carboxylating, vitamin K-dependent proteins (VKDPs), such as osteocalcin and matrix Gla-protein. When fully carboxylated, osteocalcin attracts calcium into the bones and teeth. Matrix Gla-protein (MGP) helps to prevent vascular calcification by pulling calcium out of soft tissues, including arteries and veins. Without a sufficient source of K2, both osteocalcin and MGP can remain partially uncarboxylated or completely uncarboxylated, allowing calcium to deposit in the blood vessels rather than the bone, where we need it the most.

Benefits of MegaQuinone K2-7
  • The only 320 mcg, natural vitamin K2-7 supplement on the market
  • Guaranteed stability
  • Solvent free during production
  • Soy Free, Allergen Free, Dairy Free, Gluten Free and Non-GMO
  • Vegan, Kosher and Halal
  • The only K2 supplement with Ultra Absorption Complex made of chelated minerals that are essential K2-cofactors
  • The only pharmaceutical grade, broad spectrum vitamin K2 with published safety studies
  • Supported by multiple new patents
Consider the following health conditions:
There are many published clinical studies showing that vitamin K2 halts bone mineral density loss. This is a huge benefit for people with osteopenia and osteoporosis. In fact, supplemental K2 became a first-tier treatment in Japan for osteoporosis. K2 is an essential co-factor in the activation of Gla proteins in the bone (osteocalcin) and blood vessels (matrix Gla-protein) which means that K2 is directly responsible for ensuring that calcium in the diet is deposited safely in the bones and not in the blood vessels. Without adequate K2, osteocalin remains inactive and calcium is not directed to create stronger bones.

The landmark Rotterdam Heart Study (over 4,800 subjects across a period of 10 years) demonstrated that participants who ingested the greatest quantities of vitamin K2 in their diet experienced a 57% reduction rate in death from heart disease than people who ingested the least amounts of vitamin K2. Even minimal K2 supplementation was found to decrease all-cause mortality by 25%. Without enough K2, undercarboxylated osteocalcin and MatrixGla Protein (MPG) lead to increased coronary calcification and cardiovascular disease. There are over 25 published studies confirming that deficiencies of K2 are correlated with increased arterial calcification and that prescriptive dosing with vitamin K2 can prevent this. Imagine helping your clients to reverse arterial calcification.

Over 40 published studies have demonstrated the important role of vitamin K2 against cancer. Vitamin K2 has been shown to induce apoptosis in vitro with leukemia cells, and lower the risk of prostate and liver cancer. The EPIC-Heidelberg study on K2 supplementation and prostate cancer (24,340 subjects) found an inverse association between the intake of menaquinones and prostate cancer. Vitamin K2 was also calculated to reduce prostate cancer incidence by 30%. In a study in the Journal of the American Medical Association, patients infected with hepatitis B or C (and therefore at much greater risk for developing liver cancer) were given a K2 supplement. Less than 10% of those given the supplement developed liver cancer, whereas the placebo group developed cancer at an astonishing rate of 47%.
The rates of diabetes and pre-diabetes are increasing dramatically. Over a dozen published studies have shown that K2 is protective against the development of Type 2 Diabetes, and just four weeks of K2 supplementation increases insulin sensitivity. How does this work? The mechanism is still a little bit of a mystery, yet it looks like conversion of undercarboxylated osteocalcin to carboxylated osteocalcin (for which K2 is necessary) regulates glucose metabolism, likely through β-cell dysfunction.

Dosing Instructions

Take 2 capsules daily with a meal, or as directed by your healthcare practitioner.

Research

Gelejinse J, Vermeer C, Grobbee D, et al.

Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: The Rotterdam Study. J Nutr. 2004; 134:3100-3105.

Beulens J, Bots M, Atsma F, et al.

High dietary menaquinone intake is associated with reduced coronary calcification. Atherosclerosis. 2009;203:489-493.

Bolland M, Avenell A, Baron J, et al.

Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: Meta-analysis. British Medical Journal. 2010; 341:3691.

Beulens JW, van der AD, Grobbee DE, Sluijs I, Spijkerman AM, van der Schouw YT.

Dietary phylloquinone and menaquinones intakes and risk of type 2 diabetes. Diabetes Care. 2010 Aug;33(8):1699-705.

Iwamoto J, Seki A, Sato Y, Matsumoto H, Takeda T, Yeh JK.

Vitamin K(2) prevents hyperglycemia and cancellous osteopenia in rats with streptozotocin-induced type 1 diabetes. Calcif Tissue Int. 2011 Feb;88(2):162-8.

Choi HJ, Yu J, Choi H, et al.

Vitamin K2 supplementation improves insulin sensitivity via osteocalcin metabolism: a placebo-controlled trial. Diabetes Care. 2011 Sep;34(9):e147.

Samykutty A, Shetty AV, Dakshinamoorthy G, et al.

Vitamin k2, a naturally occurring menaquinone, exerts therapeutic effects on both hormone-dependent and hormone-independent prostate cancer cells. Evid Based Complement Alternat Med. 2013;2013:287358.

Kiely, Maeve et al.

Real-time cell analysis of the inhibitory effect of vitamin K2 on adhesion and proliferation of breast cancer cells. Nutr Res. 2015;35(8): 736-743.

Mizuta T, Ozaki I, Eguchi Y, et al.

The effect of menatetrenone, a vitamin K2 analog, on disease recurrence and survival in patients with hepatocellular carcinoma after curative treatment: a pilot study. Cancer. 2006 Feb 15;106(4):867-72.

Kaipparettu BA, Ma Y, Park JH, et al.

Crosstalk from non-cancerous mitochondria can inhibit tumor properties of metastatic cells by suppressing oncogenic pathways. PLoS ONE. 2013; 8:e61747

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