A 100% spore-based, broad-spectrum probiotic shown to maintain healthy gut barrier function. This unique all-spore formula effectively RECONDITIONS the gut by promoting microbial diversity and maintaining key health-promoting, commensal gut bacteria.

MegaSporeBiotic™ does not require refrigeration and maintains a healthy gut microbiome.

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At a glance

MegaSporeBiotic is a probiotic blend of 5 Bacillus spores that have been shown to maintain healthy gut barrier and immune function. The bi-phasic life cycle of the Bacillus spores allows them to remain dormant in harsh environments until they reach more favorable environments like the human gastrointestinal tract.

Once inside the large intestine, these dormant spores can change into their active, vegetative forms and begin colonizing in the gut. This unique probiotic blend aims to RECONDITION the gut instead of reseeding with probiotic strains that cannot survive digestion or colonize the gut. MegaSporeBiotic has quickly become a household favorite among health practitioners and consumers alike.

Ingredients and formula

With the launch of MegaSporeBiotic™, Microbiome Labs completely disrupted the probiotic industry, shifting the focus from reseeding to reconditioning the gut microbiome with the help of Bacillus spores.

Total Gut Restoration Studies


Study Details and Results


Total Gut Restoration

in vitro (M-SHIME®)

Fecal samples were used in vitro to evaluate the effects on the gut microbiome using the Total Gut Restoration supplementation system. TGR supplementation resulted in short-chain fatty acids (SCFAs) production and supported intestinal barrier function and immune function.

DOI: 10.2217/fmb-2022-0066

MegaSporeBiotic™ and MegaMucosa™

The combination of MegaSpore™ and MegaMucosa™ promoted immune function and provided support to colonic mucosa.

DOI: 10.3390/nu12123607


10 days

300 million CFU of MegaSporeBiotic™ supplementation supported immune function and iron levels in mice.

DOI: 10.1002/jpen.1851


12 weeks

12 weeks of supplementation with MegaSporeBiotic™ supported triglyceride levels in study subjects.

PMID: 33041703


Administration of MegaSporeBiotic™ was shown to support liver function.

DOI: 10.3390/nu12030632


60 days

MegaSporeBiotic™ provided relief for occasional abdominal discomfort and supported elimination and digestive health in study subjects.

DOI: 10.3390/nu11091968



Study Details and Results



30 days

MegaSporeBiotic™ demonstrated cardiac-supportive and immune-supportive properties.

DOI: 10.4291/wjgp.v8.i3.117

MegaSporeBiotic™ and MegaPre™

MegaSporeBiotic™ and MegaPre™ promoted microbial diversity in the transverse and descending colon. Additionally, this synbiotic combination promoted the production of all SCFAs in the gut, including acetate, propionate, and butyrate.

DOI: 10.1016/j.ijpx.2019.100021


3 weeks

MegaSporeBiotic promoted bacterial diversity and supported ammonia, propionate, and lactate levels.

DOI: 10.1016/j.foodres.2021.110676

MegaSporeBiotic™ and antibiotics

MegaSporeBiotic™ was shown to support immune system health and help maintain normal intestinal flora.

DOI: 10.3390/microorganisms10061178

Dosing instructions

Start with 1/2 capsule or 1 full capsule with food and slowly increase to 2 capsules per day using the following protocol.

Week 1

1 capsule every other day

Week 2

1 capsule daily

Week 3+

2 capsules daily

If 1 capsule every other day causes side effects, try starting with 1/2 capsules or even 1/4 capsule in some cases. Possible side effects may include abdominal cramping, loose stools, and changes in bowel movements. Though these side effects may be uncomfortable, they are a sign that the product is working! Side effects should resolve within 2-3 days.


Robert T

Our office LOVES this product. We can’t keep it on the shelf. We use the product ourselves and our patients are excited to try it. It has GREAT science behind it. We are always learning something new when we listen to Kiran talk about the products. We look forward to sharing this product with more of our patients.

April 27, 2018

Robert T


Angie B

I had been on Digestive Advantage for 5 years and saw little improvement. Within 3 days of being on MegaSpore I could not believe how much better I felt and still continue to feel since switching. The Best Probiotic out there!!!!

April 27, 2018

Angie B


Kathy W

The most effective probiotic I have ever used, both personally and professionally.

July 23, 2017

Kathy W


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