High Potency Bacillus Subtilis


HU58™ is a high potency dose of Bacillus subtilis HU58 formulated to enhance the efficacy of MegaSporeBiotic™. HU58™ can produce over 12 targeted antibiotics in the intestines, which makes it particularly effective in balancing intestinal microflora.

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At a Glance

What is High Potency Bacillus Subtilis​?
HU58 is a high potency dose of Bacillus subtilis HU58, formulated to enhance the efficacy of MegaSporeBiotic for specific health conditions.
High Potency Bacillus Subtilis​ is recommended with:
  • Hepatic encephalopathy
  • Inflammatory bowel diseases like ulcerative colitis and Crohn’s disease
  • C. diff infections
  • Gut infections like SIBO, Candida, parasites, and more
  • Frequent travel
Benefits of High Potency Bacillus Subtilis​
  • 100% survivability in the digestive tract
  • Competitive exclusion of other bacteria, fungi, and parasites
  • 20% reduction in ammonia and hydrogen gas
  • 40% increase in short-chain fatty acid (SCFA) production
  • Decreased gut inflammation
  • Improved digestion
  • Immune modulation
  • Active gut reconditioning in antibiotic-rich environments
Bacillus subtilis is a very robust probiotic that forms an outer protective shell, known as an endospore. This impenetrable coating protects the bacterium from harsh environments, including heat, acid, pressure, light, and lack of oxygen. The rugged nature of Bacillus subtilis makes it the perfect probiotic to survive manufacturing, packaging, shipping, and ultimately digestion. In fact, this species is so resilient that researchers at California Polytechnic State University reported reviving Bacillus spores from the gut of a 25-million-year-old bee that was fossilized in amber.
Studies have demonstrated that Bacillus spores have the ability to produce their own targeted antimicrobials against harmful organisms in the gut. In this way, the spores are able to recondition the gut and foster a more diverse gut microbiome. For this reason, HU58 is especially effective as adjunct treatment for gut infections like SIBO, Candida, C. diff, parasites, and more. HU58 is even effective in the presence of broad-spectrum antibiotics, like Rifaximin, so it is safe to use in conjunction with other treatment methods.
You may have heard that “you are what you eat,” but a more accurate phrase would be that “you are what you digest and absorb.” Digestion begins in the mouth with digestive enzymes present in saliva. Your body then relies on you to chew your food into small pieces before sending it through your stomach acid for further breakdown. Once your food passes through the stomach, the final step of digestion relies almost entirely upon the digestive enzymes from your pancreas. Bacillus subtilis helps to improve digestion by increasing the production of digestive enzymes in the gut, including amylase, protease, lipase, and more.
In a phase 2 double-blind, placebo-controlled study of 40 subjects with hepatic encephalopathy, researchers found that subjects with base ammonia levels greater than 60 µmol/L saw a statistically significant reduction in ammonia levels in just 4 weeks of treatment with HU58. More research is necessary to better understand the correlation, but HU58 may be a valuable adjunct therapy for hepatic encephalopathy patients with ammonia levels above 60 µmol/L, even with antibiotic and lactulose treatment.

Dosing Instructions

Take 1-2 capsules daily with a meal, or as directed by your healthcare practitioner.


Gong Y, Li H, Li Y.

Effects of Bacillus subtilis on epithelial tight junctions of mice with inflammatory bowel disease. J Interferon Cytokine Res. 2016;36(2).

Samanya M, Yamauchi K.

Histological alterations of intestinal villi in chickens fed dried Bacillus subtilis var. natto. Comp Biochem Physiol A Mol Integr Physiol. 2002;133(1):95-104.

Serra CR, Earl AM, Barbosa TM, et al.

Sporulation during Growth in a Gut Isolate of Bacillus subtilis. J Bacteriol. 2014;196(23):4184-4196.

Hong HA, Khaneja R, Tam NMK, et al.

Bacillus subtilis isolated from the human gastrointestinal tract. Res Microbiol. 2009;160(2):134-143.

Tam NKM, Uyen NQ, Hong HA, et al.

The Intestinal Life Cycle of Bacillus subtilis and Close Relatives. Journal of Bacteriology. 2006;188(7):2692-2700. Lefevre M, Racedo SM, Ripert G, et al. Probiotic strain Bacillus subtilis CU1 stimulates immune system of elderly during common infectious disease period: a randomized, double-blind placebo-controlled study. Immun Aging. 2015;12:24.

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